产品货号：
Z12980
中文名称：
CD246/ALK抗体
英文名称：
Anti-CD246/ALK Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-CD246/ALK Antibody |
| 指标别名 | ALK;ALK tyrosine kinase receptor;Anaplastic lymphoma kinase;CD246;TFG/ALK |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC |
| 基因名称 | ALK |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human ALK(1571-1589aa LFRLRHFPCGNVNYGYQQQ),identical to the related rat and mouse sequences. |
| 实际分子量 | 176KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | ALK(Anaplastic lymphoma kinase) also known as ALK tyrosine kinase receptor or CD246(cluster of differentiation 246) is an enzyme that in humans is encoded by the ALK gene.The ALK gene is mapped on 2p23.2-p23.1.Expressed in the small intestine,testis,and brain but not in normal lymphoid cells,ALK shows greatest sequence similarity to the insulin receptor subfamily of kinases.ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system.The deduced amino acid sequences reveal that ALK is a novel receptor tyrosine kinase having a putative transmembrane domain and an extracellular domain.In Drosophila,localized Jeb activates Alk and the downstream Ras/mitogen-activated protein kinase cascade to specify a select group of visceral muscle precursors as muscle-patterning pioneers.Functional RNA interference screening on a set of these transcriptional targets revealed that CEBPB and BCL2A1 were absolutely necessary to induce cell transformation and/or to sustain growth and survival of ALK-positive ALCL cells.One particularly informative case presented a high-level gene amplification that was strictly limited to ALK,indicating that this gene may contribute on its own to neuroblastoma development.Mutated ALK proteins were overexpressed,hyperphosphorylated,and showed constitutive kinase activity.The knockdown of ALK expression in ALK-mutated cells,but also in cell lines overexpressing a wildtype ALK,led to a marked decrease of cell proliferation. |
| Uniprot ID | Q9UM73 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | anaplastic lymphoma receptor tyrosine kinase |
| 蛋白名全称 | ALK tyrosine kinase receptor |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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